Research in Real-Life (RiRL) is an independent, research-driven organisation established to cultivate initiatives, provide evidence and drive quality standards within the growing field of real-life, pragmatic research. Through our research activities we contribute to the post-marketing assessment of therapeutic interventions and help drive the current paradigm shift in healthcare evaluation towards inclusion of real-life data.
Has the evidence 'pyramid' become an outdated structure?
By employing strict controls, randomised controlled trials (RCTs) ensure high internal validity and their data currently form the bedrock of evidence used to inform regulatory decisions and clinical guidelines.
Yet despite their gravitas within traditional paradigms of pharmacovigilance, the numerous controls used by RCTs impair the generalisability of their results; strict inclusion criteria result in a highly homogenous sample of 'ideal' patients free from co-morbidities and with good adherence. Time restrictions may also prevent examination of the many long-term factors (e.g. patient tolerance) health care professionals must consider in real-life practice. The information we provide on real-world outcomes can be used to supplement and build upon RCT-derived data in order to provide a more complete therapy assessment.